[HTML][HTML] Circular RNAs in osteoarthritis: indispensable regulators and novel strategies in clinical implications

W Zhang, L Qi, R Chen, J He… - Arthritis …, 2021 - arthritis-research.biomedcentral.com
… Spliceosome at the 5′ donor site attacking the 3′ acceptor … by the cell surface pattern-recognition
receptors (PRRs) can … Investigation of the OA synovium immune cell indicated that …

[HTML][HTML] PARP inhibitors in small cell lung cancer: The underlying mechanisms and clinical implications

X Wang, X Zeng, D Li, C Zhu, X Guo, L Feng… - Biomedicine & …, 2022 - Elsevier
… and covalently attach ADP- ribose to an acceptor protein (an enzymatic reaction that can be
… growth factor receptor (EGFR), Her2, C-Met, and other cell surface receptor tyrosine kinases (…

[HTML][HTML] Biogenesis, functions, and clinical implications of circular RNAs in non-small cell lung cancer

Y Liu, X Ao, W Yu, Y Zhang, J Wang - Molecular Therapy-Nucleic Acids, 2022 - cell.com
… Moreover, we highlight their clinical implications in NSCLC treatment. … According to its
pathological features, LC is usually classified into two subtypes: small cell LC and non-small cell

[HTML][HTML] The functional roles, cross-talk and clinical implications of m6A modification and circRNA in hepatocellular carcinoma

S Qin, Y Mao, X Chen, J Xiao, Y Qin… - International Journal of …, 2021 - ncbi.nlm.nih.gov
… multiple functions in a variety of cellular processes. Although the … , their cross-talk, and clinical
implications have not been fully … donor site to the upstream splice acceptor site and forms a …

The role of non-coding RNAs in ABC transporters regulation and their clinical implications of multidrug resistance in cancer

Y Wang, Y Wang, Z Qin, S Cai, L Yu… - Expert Opinion on …, 2021 - Taylor & Francis
… been revealed, including disturbance of diverse cell signaling involved in cells apoptosis, …
with nuclear receptors [Citation5], post-translational modification as well as cell signaling …

Ischemia-reperfusion injury in marginal liver grafts and the role of hypothermic machine perfusion: molecular mechanisms and clinical implications

Z Czigany, I Lurje, M Schmelzle, W Schöning… - Journal of Clinical …, 2020 - mdpi.com
cell metabolism and reduce the oxygen demand of the allograft. However, the cellular
of the CoQ pool or flavin mononucleotide (acceptor of electrons from NADH), decrease the …

[HTML][HTML] Biological and clinical insight from analysis of the tumor b-cell receptor structure and function in chronic lymphocytic leukemia

F Forconi, SA Lanham, G Chiodin - Cancers, 2022 - mdpi.com
clinical implications associated with the analysis of the immunoglobulin (also known as B-cell
receptor) … the asparagine-x-serine/threonine acceptor sequence motifs. For the majority of …

Cellular effects and clinical implications of SLC2A3 copy number variation

GC Ziegler, P Almos, RV McNeill… - Journal of Cellular …, 2020 - Wiley Online Library
… In cancer cells, GLUT3 overexpression contributes to the Warburg effect by answering the
cell's increased glycolytic demands. The SLC2A3 gene locus at chromosome 12p13.31 is …

The Yin and Yang-Like Clinical Implications of the CDKN2A/ARF/CDKN2B Gene Cluster in Acute Lymphoblastic Leukemia

C González-Gil, J Ribera, JM Ribera, E Genescà - Genes, 2021 - mdpi.com
… -cell acute lymphoblastic leukemia (T-ALL) and account for roughly 30% of copy number
alterations found in B-cell-… CDKN2A exon two at the same acceptor site but in a different reading …

[HTML][HTML] New insights into the regulatory roles of extracellular vesicles in tumor angiogenesis and their clinical implications

M Huang, Y Lei, Y Zhong, C Chung, M Wang… - Frontiers in Cell and …, 2021 - frontiersin.org
… and their mechanisms, and we highlight the clinical implications of EVs in bodily fluids as …
Ephrin type B receptor 2 (EPHB2) in small EVs derived from head and neck squamous cell